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JAS239

CAT: 0931-T70345-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70345-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1630288-74-2
Target
Others
Related Pathways
Others
Bioactivity
JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibody blockade prevented cellular retention of JAS239 indicating direct interaction with ChoKα independent of the choline transporters and catabolic choline pathways. In mice bearing orthotopic MCF7 breast xenografts, optical imaging with JAS239 distinguished tumors overexpressing ChoKα from their empty vector counterparts and delineated tumor margins.
Smiles
C(CO)N1C=2C(C(C)(C)C1=CC=CC=CC=CC3=[N+](CCO)C=4C(C3(C)C)=CC=CC4)=CC=CC2.[Cl-]
Molecular Formula
C31H37ClN2O2
Molecular Weight
505.09
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
M12448-01JAS239

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