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Mevidalen HBA

CAT: 0931-T70326-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70326-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1638669-32-5
Target
Others
Related Pathways
Others
Bioactivity
Mevidalen, also known as LY3154207, is a novel, potent, and subtype selective human D1 positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50 = 3 nM) . In contrast to orthosteric agonists, LY3154207 showed a distinct pharmacological profile without a bell-shaped dose-response relationship or tachyphylaxis in preclinical models. Identification of a crystalline form of free LY3154207 from the discovery lots was not successful. Instead, a novel cocrystal form with superior solubility was discovered and determined to be suitable for development. LY3154207 is now in clinical development as a potential first-in-class D1 PAM for Lewy body dementia..
Smiles
OC(=O)c1ccc(O)cc1.C[C@@H]1N([C@@H](CO)Cc2c(CCC(C)(C)O)cccc12)C(=O)Cc1c(Cl)cccc1Cl
Molecular Formula
C31H35Cl2NO6
Molecular Weight
588.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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