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AEG40730 HCl

CAT: 0931-T70096-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T70096-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1883545-50-3
Target
Others
Related Pathways
Others
Bioactivity
AEG40730 is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG40730 binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in RIP1 ubiquitination. Treatment with nanomolar concentrations of AEG40730 resulted in the loss of both XIAP and c-IAP1 proteins, albeit with different kinetics.
Smiles
Cl.Cl.CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)OCC#CC#CCO[C@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N1CCC[C@H]1CN(CCc1ccccc1)C(=O)C(F)(F)F)C(=O)N1CCC[C@H]1CN(CCc1ccccc1)C(=O)C(F)(F)F
Molecular Formula
C52H70Cl2F6N8O8
Molecular Weight
1120.0704
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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CatalogName
MBS5812639AEG40730 HCl

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