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MDK6465

CAT: 0931-T70069-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T70069-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1900686-46-5
Target
Others
Related Pathways
Others
Bioactivity
MDK6465, also known as PCSK9-IN-8b, is a novel liver-targeted inhibitor of ribosomal synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) . MDK6465 has CAS#1900686-46-5. the last 4 digits are used in its name.
Smiles
CN1C(=C(C=N1)C2=C(F)C=C(C(N(C3=C(Cl)C=CC=N3)[C@@H]4CCCNC4)=O)C=C2)C=5N([C@@H](OC(OCC)=O)C)N=NN5
Molecular Formula
C27H29ClFN9O4
Molecular Weight
598.03
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Pf-06815345

PF-06815345 is under investigation in clinical trial NCT02654899 (Single Dose Study of PF-06815345 in Healthy Subjects).

CAS Number1900686-46-5
PubChem CID121276853
IUPAC Name[(1S)-1-[5-[4-[4-[(3-chloro-2-pyridinyl)-[(3R)-piperidin-3-yl]carbamoyl]-2-fluorophenyl]-1-methylpyrazol-5-yl]tetrazol-1-yl]ethyl] ethyl carbonate
Molecular FormulaC27H29ClFN9O4
Molecular Weight598.0
XLogP3.4
Topological Polar Surface Area142
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count10
Heavy Atom Count42
Formal Charge0
Complexity927
SMILES
CCOC(=O)O[C@@H](C)N1C(=NN=N1)C2=C(C=NN2C)C3=C(C=C(C=C3)C(=O)N([C@@H]4CCCNC4)C5=C(C=CC=N5)Cl)F
InChI
InChI=1S/C27H29ClFN9O4/c1-4-41-27(40)42-16(2)38-25(33-34-35-38)23-20(15-32-36(23)3)19-10-9-17(13-22(19)29)26(39)37(18-7-5-11-30-14-18)24-21(28)8-6-12-31-24/h6,8-10,12-13,15-16,18,30H,4-5,7,11,14H2,1-3H3/t16-,18+/m0/s1
InChIKey
QTBYVAZRKWOIDU-FUHWJXTLSA-N
Chemical Structure
2D Structure
2D structure of Pf-06815345
CAS: 1900686-46-5
CID: 121276853
Formula: C27H29ClFN9O4
MW: 598.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight598.0
XLogP33.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count10
Exact Mass597.2015063
Monoisotopic Mass597.2015063
Topological Polar Surface Area142 Ų
Heavy Atom Count42
Formal Charge0
Complexity927
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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