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AZD5718

CAT: 0931-T69970-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T69970-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2041076-43-9
Target
Others|||FLAP
Related Pathways
Immunology/Inflammation|||Others
Bioactivity
AZD5718 is a potent and selective FLAP inhibitor (IC50 = 2.0 nM) for Treatment of Coronary Artery Disease. AZD5718 demonstrated a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Preclinical toxicology studies in rat and dog did not show any serious adverse events of clinical significance. Currently, AZD5718 is evaluated in a phase 2a study for treatment of coronary artery disease.
Smiles
CC=1C=C(N(N1)C2CCCCO2)C3=CC=C(C(=O)[C@H]4[C@H](C(NC5=C6N(N=C5)CCNC6=O)=O)CCCC4)C=C3
Molecular Formula
C29H34N6O4
Molecular Weight
530.62
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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