Roxadustat-d5

• Target :

  Ferroptosis|||HIF/HIF Prolyl-Hydroxylase

• Related Pathways :

  Chromatin/Epigenetic|||Apoptosis|||Metabolism

• Bioactivity :

  Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively) . It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all) . Roxadustat (10-200 µM) stabilizes HIF-1? and HIF-2? in Hep3B hepatocellular carcinoma cells. It increases levels of secreted erythropoietin in Hep3B cells in a concentration-dependent manner and increases erythropoiesis in rats when administered at doses of 25 and 50 mg/kg. Roxadustat reverses anemia in a rat model of chronic inflammation induced by peptidoglycan-polysaccharide, as well as a rat model of chronic kidney disease induced by 5/6 nephrectomy. It reduces tumor growth and increases survival in a murine Lewis lung carcin......

• Smiles :

  CC=1C2=C(C(O)=C(C(NCC(O)=O)=O)N1)C=CC(OC3=C(C(=C(C(=C3[2H])[2H])[2H])[2H])[2H])=C2

• Molecular Formula :

  C19H11D5N2O5

• Molecular Weight :

  357.37

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2043026-13-5