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NLG802 HCl

CAT: 0931-T69944-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69944-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2071684-09-6
Target
Others
Related Pathways
Others
Bioactivity
NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs) .
Smiles
Cl.CC(C)C[C@H](N)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(O)=O
Molecular Formula
C18H26ClN3O3
Molecular Weight
367.874
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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