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AMP423

CAT: 0931-T69821-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T69821-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
219501-57-2
Target
Others
Related Pathways
Others
Bioactivity
AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma tumors, with a median tumor growth delay (T-C) of 21 days (P = 0.0002) and 5 days (P = 0.004), respectively, and a median tumor growth inhibition (T/C) of 33.3% (P = 0.03) and 82% (P = 0.01), respectively. In non-tumor-bearing mice, AMP423 was not myelosuppressive.
Smiles
N(C(=O)N1C(C#N)C1)C=2C3=C(C=CC2)C=CC=C3
Molecular Formula
C14H11N3O
Molecular Weight
237.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-Cyano-N-naphthalen-1-ylaziridine-1-carboxamide
CAS Number219501-57-2
PubChem CID9921068
IUPAC Name2-cyano-N-naphthalen-1-ylaziridine-1-carboxamide
Molecular FormulaC14H11N3O
Molecular Weight237.26
XLogP2
Topological Polar Surface Area55.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity386
SMILES
C1C(N1C(=O)NC2=CC=CC3=CC=CC=C32)C#N
InChI
InChI=1S/C14H11N3O/c15-8-11-9-17(11)14(18)16-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11H,9H2,(H,16,18)
InChIKey
WTPBNYGXGYMXNL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Cyano-N-naphthalen-1-ylaziridine-1-carboxamide
CAS: 219501-57-2
CID: 9921068
Formula: C14H11N3O
MW: 237.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight237.26
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass237.090211983
Monoisotopic Mass237.090211983
Topological Polar Surface Area55.9 Ų
Heavy Atom Count18
Formal Charge0
Complexity386
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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