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Flizasertib

CAT: 0931-T69711-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T69711-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2268739-68-8
Target
Serine Protease, RIP kinase
Related Pathways
Apoptosis, NF-κB, Proteases/Proteasome
Purity
>99.99%
Bioactivity
Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1 (Receptor-interacting serine/threonine-protein kinase 1), which has anti-inflammatory and therapeutic effects on immune disorders.
Smiles
F[C@@H]1C=2N([C@@H](C1)C3=CC=CC=C3)N=C(C(=O)C4CC4)N2
Molecular Formula
C15H14FN3O
Molecular Weight
271.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Flizasertib

Flizasertib is a small molecule drug. The usage of the INN stem '-sertib' in the name indicates that Flizasertib is a serine/threonine kinase inhibitor. Flizasertib is under investigation in clinical trial NCT06602453 (A Study to Evaluate the Efficacy and Safety of GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE)). Flizasertib has a monoisotopic molecular weight of 271.11 Da.

CAS Number2268739-68-8
PubChem CID137408242
IUPAC Namecyclopropyl-[(5S,7S)-7-fluoro-5-phenyl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-yl]methanone
Molecular FormulaC15H14FN3O
Molecular Weight271.29
XLogP2.5
Topological Polar Surface Area47.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity395
SMILES
C1CC1C(=O)C2=NN3[C@@H](C[C@@H](C3=N2)F)C4=CC=CC=C4
InChI
InChI=1S/C15H14FN3O/c16-11-8-12(9-4-2-1-3-5-9)19-15(11)17-14(18-19)13(20)10-6-7-10/h1-5,10-12H,6-8H2/t11-,12-/m0/s1
InChIKey
LMXPZWQVDDSYHH-RYUDHWBXSA-N
Chemical Structure
2D Structure
2D structure of Flizasertib
CAS: 2268739-68-8
CID: 137408242
Formula: C15H14FN3O
MW: 271.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight271.29
XLogP32.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass271.11209024
Monoisotopic Mass271.11209024
Topological Polar Surface Area47.8 Ų
Heavy Atom Count20
Formal Charge0
Complexity395
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP20048-01Flizasertib

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