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BR103354

CAT: 0931-T69603-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69603-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2505339-87-5
Target
Others
Related Pathways
Others
Bioactivity
BR103354 is a novel fibroblast activation protein (FAP) inhibitor with anti-diabetic and anti-steatotic effects. BR103354 inhibited FAP with an IC50 value of 14 nM, showing high selectivity against dipeptidyl peptidase (DPP) -related enzymes and prolyl oligopeptidase (PREP) . BR103354 exhibited good pharmacokinetic properties as evidenced by oral bioavailability of 48.4% and minimal hERG inhibition. Single co-administration of BR103354 with hFGF21 reduced nonfasting blood glucose concentrations, in association with increased intact form of hFGF21 in ob/ob mice. BR103354 acts as an effective FAP inhibitor in vitro and in vivo, thereby demonstrating its potential application as an anti-diabetic and anti-NASH agent.
Smiles
C(CNC(=O)C=1N=C(CC2=CC=C(C#N)C=C2)SC1)(=O)N3[C@H](C#N)CC(F)(F)C3
Molecular Formula
C19H15F2N5O2S
Molecular Weight
415.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5812150BR103354

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