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Bexotegrast HCl

CAT: 0931-T69517-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69517-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2775365-40-5
Target
Integrin, Others
Related Pathways
Others, Cytoskeletal Signaling
Bioactivity
Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC) . These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts.
Smiles
N([C@@H](CCN(CCCCC=1NC=2C(=CC1)CCCN2)CCOC)C(O)=O)C=3C4=C(N=CN3)C=CC=C4.Cl.Cl
Molecular Formula
C27H38Cl2N6O3
Molecular Weight
565.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-137561-01Bexotegrast
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HY-137561ABexotegrast (hydrochloride)

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