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Ozarelix

CAT: 0931-T69492-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69492-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
295350-45-7
Target
Apoptosis, GNRH Receptor
Related Pathways
GPCR/G Protein, Apoptosis
Bioactivity
Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer, BPH, infertility, uterine myoma and endometriosis. BPH is a non-cancerous enlargement of the prostate that is caused by testosterone. Unlike LHRH agonists, ozarelix has the potential to reduce testosterone just enough to reduce both prostate size and symptoms without the severe side effects associated with a reduction in testosterone.
Smiles
C([C@@H](NC([C@@H](NC([C@H](NC([C@H](CC1=CC=C(O)C=C1)N(C([C@@H](NC([C@@H](CC=2C=CC=NC2)NC([C@@H](CC3=CC=C(Cl)C=C3)NC([C@@H](CC4=CC5=C(C=C4)C=CC=C5)NC(C)=O)=O)=O)=O)CO)=O)C)=O)CCCCNC(N)=O)=O)CCCC)=O)CCCNC(=N)N)(=O)N6[C@H](C(N[C@@H](C(N)=O)C)=O)CCC6
Molecular Formula
C72H96ClN17O14
Molecular Weight
1459.09
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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A12350-25Ozarelix 25mg
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