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Sagopilone

CAT: 0931-T69480-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69480-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
305841-29-6
Target
Others, Microtubule Associated
Related Pathways
Others, Cytoskeletal Signaling
Bioactivity
Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum.
Smiles
C[C@@]12[C@@](O1)(C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](CC=C)[C@@H](O)[C@@H](C)CCC2)C=3C=C4C(=CC3)SC(C)=N4)[H]
Molecular Formula
C30H41NO6S
Molecular Weight
543.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

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MBS3840304-01Sagopilone
A14328-10Sagopilone 10mg
A14328-25Sagopilone 25mg
A14328-100Sagopilone 100mg
A14328-50Sagopilone 50mg
A14328-5Sagopilone 5mg

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