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MT477

CAT: 0931-T69438-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69438-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
328069-91-6
Target
PKC, Others
Related Pathways
Chromatin/Epigenetic, Others, Cytoskeletal Signaling
Bioactivity
MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays.
Smiles
C(OC)(=O)C=1C2(C=3C=4C(N(C(CN5C(=O)CCC5=O)=O)C(C)(C)C3SC1C(OC)=O)=C(OC)C=CC4)SC(C(OC)=O)=C(C(OC)=O)S2
Molecular Formula
C31H30N2O12S3
Molecular Weight
718.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-122241MT477

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