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Nicotinamide-d4

CAT: 0931-T69395-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T69395-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
347841-88-7
Target
Sirtuin, Endogenous Metabolite
Related Pathways
Chromatin/Epigenetic, Metabolism, DNA Damage/DNA Repair
Purity
0.99746
Bioactivity
Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 μM) . Nicotinamide (10 μM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes. Nicotinamide (40 μM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC. Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.
Smiles
[2H]c1nc([2H])c(c([2H])c1[2H])C(N)=O
Molecular Formula
C6H2D4N2O
Molecular Weight
126.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(~2~H_4_)Pyridine-3-carboxamide
CAS Number347841-88-7
PubChem CID15554909
IUPAC Name2,4,5,6-tetradeuteriopyridine-3-carboxamide
Molecular FormulaC6H6N2O
Molecular Weight126.15
XLogP-0.4
Topological Polar Surface Area56
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count9
Formal Charge0
Complexity114
SMILES
[2H]C1=C(C(=C(N=C1[2H])[2H])C(=O)N)[2H]
InChI
InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)/i1D,2D,3D,4D
InChIKey
DFPAKSUCGFBDDF-RHQRLBAQSA-N
Chemical Structure
2D Structure
2D structure of (~2~H_4_)Pyridine-3-carboxamide
CAS: 347841-88-7
CID: 15554909
Formula: C6H6N2O
MW: 126.15
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight126.15
XLogP3-0.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass126.073119803
Monoisotopic Mass126.073119803
Topological Polar Surface Area56 Ų
Heavy Atom Count9
Formal Charge0
Complexity114
Isotope Atom Count4
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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T33662-01Nicotinamide ascorbate
TMIJ-0463-01Thiamethoxam-d4 (oxadiazine-d4)
T6220-01Nicotinamide riboside chloride
T40059Nicotinamide riboside tartrate
T0617-01Nicotinamide N-oxide
T7869-01N- (Hydroxymethyl) nicotinamide

Alternative Products

CatalogName
AR-N08598-01Nicotinamide-d4
018096Nicotinamide-d4 (Major)
CS-O-51725Nicotinamide Riboside-D4
469744-01β-Nicotinamide-d4 Mononucleotide (d4-major)
TRC-N407768-1MGBeta-Nicotinamide-d4 Mononucleotide (d4-major)
TRC-N407762-50MGNicotinamide-d4 N-Oxide (d4 Major)
HY-W767484Nicotinamide riboside-d4 (triflate)
018098Nicotinamide-d4 N-Oxide
AR-N08586-01Nicotinamide Adenine Dinucleotide-d4
CS-O-44691Nicotinamide mononucleotide (NMN) -D4

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