Nicotinamide-d4

CAT: 0931-T69395-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T69395-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
347841-88-7
Target
Sirtuin|||Endogenous Metabolite
Related Pathways
Chromatin/Epigenetic|||Metabolism|||DNA Damage/DNA Repair
Purity
0.9975
Bioactivity
Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM) . Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes. Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC. Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.
Smiles
[2H]c1nc([2H])c(c([2H])c1[2H])C(N)=O
Molecular Formula
C6H2D4N2O
Molecular Weight
126.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

CatalogName
N2561-75Nicotinamide-d4
018096Nicotinamide-d4 (Major)
469744-01β-Nicotinamide-d4 Mononucleotide (d4-major)
TRC-N407768-10MGBeta-Nicotinamide-d4 Mononucleotide (d4-major)
TRC-N407762-50MGNicotinamide-d4 N-Oxide (d4 Major)
018098Nicotinamide-d4 N-Oxide
HY-W767484Nicotinamide riboside-d4 (triflate)
HY-W701397-01Nicotinamide N-oxide-d4
TRC-H942367-25MGN-(2-Hydroxyethyl)nicotinamide-d4
sc-478217β-Nicotinamide-d4 Mononucleotide (d3-major)

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