Ki23057

CAT: 0931-T69162-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T69162-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

516523-31-2

Target

Others, Apoptosis

Related Pathways

Apoptosis, Others

Bioactivity

Ki23057 is a a FGFR2 inhibitor, which enhances the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs. Ki23057 might be therapeutically promising for treating drug-resistant gastric cancer cells, especially when used in combination with SN38, PTX, or VP16. The apoptosis process might be the main mechanism underlying the synergistic effect of these combinations. The ERCC1 and p53 genes may play an integral role in the synergism between Ki23057 and chemotherapeutic agents in drug-resistant cell lines. (source: Cancer Lett. 2011 Aug 1;307 (1) :47-52) .

Smiles

O(C=1C2=C(C=C(OCCNCCO)C(OC)=C2)N=CC1)C3=CC=C(NC4=CC=C(C(C)(C)C)C=C4)C=C3

Molecular Formula

C30H35N3O4

Molecular Weight

501.62

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
MBS5811713	Ki23057

Ki23057

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