Dextrallorphan

CAT: 0931-T69060-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T69060-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

5822-43-5

Target

Others

Related Pathways

Others

Bioactivity

Dextrallorphan (DXA) is an chemical of the morphinan class that is used in scientific research. It acts as a σ1 receptor agonist and NMDA receptor antagonist. It has no significant affinity for the σ2, μ-opioid, or δ-opioid receptor, or for the serotonin or norepinephrine transporter. As an NMDA receptor antagonist, in vivo, it is approximately twice as potent as dextromethorphan, and five-fold less potent than dextrorphan. Dextrallorphan was found to have a half maximal inhibitory concentration (IC50) for binding to the pituitary and brain receptor of 10,000 ± 1000 nM and 10,000 ± 1500 nM, respectively. While its stereoisomer, levallorphan, had a 10,000 times more potent dose, thus proving that binding to these receptors is stereospecific.

Smiles

C(C=C)N1[C@@]2([C@@]3([C@@](C=4C(C2)=CC=C(O)C4)(CC1)CCCC3)[H])[H]

Molecular Formula

C19H25NO

Molecular Weight

283.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
GTR19210871-01	Dextrallorphan

Dextrallorphan

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