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Fazarabine

CAT: 0931-T68917-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68917-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
65886-71-7
Target
Others
Related Pathways
Others
Bioactivity
Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug.
Smiles
O[C@@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)N=C2
Molecular Formula
C8H12N4O5
Molecular Weight
244.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5811472Fazarabine

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