SU-11752

• Target:

  Others|||PI3K|||DNA-PK

• Related Pathways:

  Others|||PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair

• Bioactivity:

  SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.

• Smiles:

  C(=C1C=2C(NC1=O)=CC=C(S(NC3=CC=CC=C3)(=O)=O)C2)C4=C(CC)C(CCC(O)=O)=C(CC)N4

• Molecular Formula:

  C26H27N3O5S

• Molecular Weight:

  493.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  688036-19-3