SU-11752

CAT: 0931-MF-0143630-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0143630-01Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
688036-19-3
Target
Others|||PI3K|||DNA-PK
Related Pathways
Others|||PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair
Bioactivity
SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.
Smiles
C(=C1C=2C(NC1=O)=CC=C(S(NC3=CC=CC=C3)(=O)=O)C2)C4=C(CC)C(CCC(O)=O)=C(CC)N4
Molecular Formula
C26H27N3O5S
Molecular Weight
493.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
MF-0137775-01SU-200
MF-0040490-01Su 9055
MF-0096228-01SU 10603
MF-0138238-01SU 2941
MF-0095288-01SU 5616
MF-0013741-01SU 5402
MF-0013202-01SU 4942
MF-0049570SU 15049A
MF-0152210SU 14074
MF-0019438-01SU 4313

Alternative Products

CatalogName
MBS3605625-01SU-11752
MBS3617078-01SU 4981
MBS3608149-01SU 4313
MBS3608148-01SU 5214
MBS3604300-01SU-9516
MBS3842128-01SU 5205
MBS3842129-01SU-5408
MBS386233-01SU-5402
MBS808180-01SU 4312
MBS6115561-01SU-5614

Popular Products