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SU-11752

CAT: 0931-T68870-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68870-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
688036-19-3
Target
Others, PI3K, DNA-PK
Related Pathways
Others, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair
Bioactivity
SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.
Smiles
C(=C1C=2C(NC1=O)=CC=C(S(NC3=CC=CC=C3)(=O)=O)C2)C4=C(CC)C(CCC(O)=O)=C(CC)N4
Molecular Formula
C26H27N3O5S
Molecular Weight
493.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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