Iso-Fludelone

• Target:

  Others|||Microtubule Associated

• Related Pathways:

  Cytoskeletal Signaling|||Others

• Bioactivity:

  Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as well as reduced toxicity. In addition, this agent is a not a substrate of the P-glycoprotein (P-gp), a multidrug resistance pump often overexpressed in cancer cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) .

• Smiles:

  C(=C\C=1C=C(C)ON1)(\C)/[C@@H]2C/C=C(\C(F)(F)F)/C/C=C/[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2

• Molecular Formula:

  C27H36F3NO6

• Molecular Weight:

  527.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  691868-19-6