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Ellipticine quinone

CAT: 0931-T68788-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68788-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
73326-98-4
Target
Dynamin, Reactive Oxygen Species, Others
Related Pathways
Metabolism, Others, NF-κB, Cytoskeletal Signaling, Immunology/Inflammation
Bioactivity
Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.) . Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury.
Smiles
O=C1C2=C(C(=O)C=3C1=CN=CC3)NC=4C2=CC=CC4
Molecular Formula
C15H8N2O2
Molecular Weight
248.24
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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GTR19211159-01Ellipticine quinone
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