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Melogliptin

CAT: 0931-T68491-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T68491-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
868771-57-7
Target
Others
Related Pathways
Others
Bioactivity
Melogliptin, also known as EMD-675992 and GRC-8200, is a potent and selective a dipeptidyl peptidase IV (DPP-IV) inhibitor potentially for treatment of type II diabetes. Melogliptin significantly reduced HbA1c from baseline as compared to placebo with a mean average reduction of 0.75 percent in patients receiving 50mg twice daily dose and 0.60 percent in patients receiving 100 mg once daily dose.
Smiles
C(CN[C@H]1C[C@@H](CN2C=NC=N2)CC1)(=O)N3[C@H](C#N)C[C@H](F)C3
Molecular Formula
C15H21FN6O
Molecular Weight
320.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Melogliptin

Melogliptin is a small molecule drug. The usage of the INN stem '-gliptin' in the name indicates that Melogliptin is a dipeptidyl aminopeptidase-IV inhibitor. Melogliptin has a monoisotopic molecular weight of 320.18 Da.

CAS Number868771-57-7
PubChem CID11623906
IUPAC Name(2S,4S)-4-fluoro-1-[2-[[(1R,3S)-3-(1,2,4-triazol-1-ylmethyl)cyclopentyl]amino]acetyl]pyrrolidine-2-carbonitrile
Molecular FormulaC15H21FN6O
Molecular Weight320.37
XLogP0.6
Topological Polar Surface Area86.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity480
SMILES
C1C[C@H](C[C@H]1CN2C=NC=N2)NCC(=O)N3C[C@H](C[C@H]3C#N)F
InChI
InChI=1S/C15H21FN6O/c16-12-4-14(5-17)22(8-12)15(23)6-19-13-2-1-11(3-13)7-21-10-18-9-20-21/h9-14,19H,1-4,6-8H2/t11-,12-,13+,14-/m0/s1
InChIKey
JSYGLDMGERSRPC-FQUUOJAGSA-N
Chemical Structure
2D Structure
2D structure of Melogliptin
CAS: 868771-57-7
CID: 11623906
Formula: C15H21FN6O
MW: 320.37
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.37
XLogP30.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass320.17608748
Monoisotopic Mass320.17608748
Topological Polar Surface Area86.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-10288Melogliptin

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