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RO4927350

CAT: 0931-T68459-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68459-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
876755-27-0
Target
Others, MEK
Related Pathways
MAPK, Others
Bioactivity
RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a broad spectrum of tumor models. RO4927350 inhibits not only ERK1/2 but also MEK1/2 phosphorylation. In cancer cells, high basal levels of phospho-MEK1/2 rather than phospho-ERK1/2 seem to correlate with greater sensitivity to RO4927350. Furthermore, RO4927350 prevents a feedback increase in MEK phosphorylation, which has been observed with other MEK inhibitors. RO4927350 represents a novel therapeutic modality in cancers with aberrant MAPK pathway activation.
Smiles
[C@H]([C@@H](C)C1=CC=CC=C1)(C(NC2=NC(C(CC)=O)=CS2)=O)N3C(=O)[C@H](NC3=O)C4=CC=C(OCCO)C=C4
Molecular Formula
C27H28N4O6S
Molecular Weight
536.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5811020RO4927350
A11247-25RO4927350 25mg
A11247-5RO4927350 5mg
A11247-100RO4927350 100mg
A11247-50RO4927350 50mg
A11247-10RO4927350 10mg

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