LY2457546

CAT: 0931-T68389-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T68389-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

908265-94-1

Target

Others

Related Pathways

Others

Bioactivity

LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 syngeneic rat mammary tumor models. Additionally, LY2457546 caused complete regression of well-established tumors in an acute myelogenous leukemia (AML) FLT3-ITD mutant xenograft tumor model. The unique spectrum of target activity, potent in vivo anti-tumor efficacy in a variety of rodent and human solid tumor models, exquisite potency against a clinically relevant model of AML, and non-clinical safety profile justify the advancement of LY2457546 into clinical testing. (source: Invest New D......

Smiles

FC=1C=C(C=2N3C(C=C(C=C3)C=4C=C(C)N=CC4)=NC2)C=CC1CC(NC5=CC(C(F)(F)F)=CC=C5)=O

Molecular Formula

C28H20F4N4O

Molecular Weight

504.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
MBS5810952	LY2457546

LY2457546

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