BIIB028

CAT: 0931-T68383-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T68383-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
911398-13-5
Target
Others|||HSP
Related Pathways
Cytoskeletal Signaling|||Others|||Metabolism
Bioactivity
BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses.
Smiles
C(#CCCOP(=O)(O)O)C=1C=2C(N(CC3=C(C)C(OC)=C(C)C=N3)C1)=NC(N)=NC2Cl
Molecular Formula
C19H21ClN5O5P
Molecular Weight
465.83
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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