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HS56

CAT: 0931-T68341-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68341-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
922050-57-5
Target
Pim, Others, DAPK
Related Pathways
JAK/STAT signaling, Others, Chromatin/Epigenetic, Apoptosis
Bioactivity
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor, displaying K_i values of 0.26 μM for DAPK3, 0.208 μM for Pim-3, 2.94 μM for Pim-1, and >100 μM for Pim-2. This compound effectively inhibits LC20 phosphorylation and smooth muscle contraction, and reduces blood pressure in spontaneously hypertensive mice, making it a valuable tool for hypertension research [HS-56].
Smiles
O=C1C2=C(N(N=C2)C3=CC(Cl)=CC=C3)NC(SCC#N)=N1
Molecular Formula
C13H8ClN5OS
Molecular Weight
317.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19212401-01HS56

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