KCN1

CAT: 0931-T68324-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T68324-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

927823-01-6

Target

HIF/HIF Prolyl-Hydroxylase, Others, Histone Acetyltransferase

Related Pathways

Chromatin/Epigenetic, Metabolism, Others

Bioactivity

KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF reporter gene activity in several glioma cell lines at the nanomolar level. KCN1 also downregulated transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE) -dependent manner. KCN1 potently inhibited the growth of subcutaneous malignant glioma tumor xenografts with minimal adverse effects on the host.

Smiles

N(S(=O)(=O)C1=CC(OC)=C(OC)C=C1)(CC=2C=C3C(=CC2)OC(C)(C)C=C3)C4=CC=CC=C4

Molecular Formula

C26H27NO5S

Molecular Weight

465.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
MBS5810887	KCN1

KCN1

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