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VJ115

CAT: 0931-T68317-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T68317-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
929256-79-1
Target
Others
Related Pathways
Others
Bioactivity
VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cytoskeletal reorganization and angiogenesis.
Smiles
C(\C=1C=2C(N(CC3=CC=CC=C3)C1)=CC=CC2)=C/4\N5CCC(C4O)CC5
Molecular Formula
C23H24N2O
Molecular Weight
344.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(2Z)-2-[(1-benzylindol-3-yl)methylidene]-1-azabicyclo[2.2.2]octan-3-ol
CAS Number929256-79-1
PubChem CID10088884
IUPAC Name(2Z)-2-[(1-benzylindol-3-yl)methylidene]-1-azabicyclo[2.2.2]octan-3-ol
Molecular FormulaC23H24N2O
Molecular Weight344.4
XLogP3.8
Topological Polar Surface Area28.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity518
SMILES
C1CN\2CCC1C(/C2=C/C3=CN(C4=CC=CC=C43)CC5=CC=CC=C5)O
InChI
InChI=1S/C23H24N2O/c26-23-18-10-12-24(13-11-18)22(23)14-19-16-25(15-17-6-2-1-3-7-17)21-9-5-4-8-20(19)21/h1-9,14,16,18,23,26H,10-13,15H2/b22-14-
InChIKey
QSSJQRUIQVSAQK-HMAPJEAMSA-N
Chemical Structure
2D Structure
2D structure of (2Z)-2-[(1-benzylindol-3-yl)methylidene]-1-azabicyclo[2.2.2]octan-3-ol
CAS: 929256-79-1
CID: 10088884
Formula: C23H24N2O
MW: 344.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight344.4
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass344.188863393
Monoisotopic Mass344.188863393
Topological Polar Surface Area28.4 Ų
Heavy Atom Count26
Formal Charge0
Complexity518
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5810881VJ115

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