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SB1578

CAT: 0931-T68296-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68296-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
937273-04-6
Target
Others
Related Pathways
Others
Bioactivity
SB1578, also known as ONX-0805, is a novel, orally bioavailable JAK2 inhibitor with specificity for JAK2 within the JAK family and also potent activity against FLT3 and c-Fms. SB1578 blocks the activation of these kinases and their downstream signaling in pertinent cells, leading to inhibition of pathological cellular responses. The biochemical and cellular activities of SB1578 translate into its high efficacy in two rodent models of arthritis.
Smiles
O(CCN1CCCC1)C=2C3=CC(N=C4NC(C=5OC(=CC5)COC/C=C/COC3)=CC=N4)=CC2
Molecular Formula
C26H30N4O4
Molecular Weight
462.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19211582-01SB1578

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