AEG40826

CAT: 0931-T68262-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T68262-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

949963-04-6

Target

Others

Related Pathways

Others

Bioactivity

AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains.

Smiles

C([C@@H](NC([C@@H](NC)C)=O)[C@@](C)(C)C)(=O)N1[C@H](C(N[C@H]2C=3C(CCC2)=CC=CC3)=O)C[C@H](NC(=O)C4=CC=C(C(N[C@@H]5CN(C([C@@H](NC([C@@H](NC)C)=O)C(C)(C)C)=O)[C@H](C(N[C@H]6C=7C(CCC6)=CC=CC7)=O)C5)=O)C=C4)C1

Molecular Formula

C58H80N10O8

Molecular Weight

1045.32

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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MBS5810826	AEG40826

AEG40826

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