Peraclopone

CAT: 0931-T68219-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T68219-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

96164-19-1

Target

Others

Related Pathways

Others

Bioactivity

Peraclopone is a hypolidemic drug. It is an inhibitor of 7-Dehydrocholesterol reductase. Peraclopone potently inhibits the final step in cholesterol biosynthesis. Feeding this agent to rats leads to a rapid replacement of membrane cholesterol with its immediate precursor 7-dehydrocholesterol, and a dramatic reduction in plasma sterol concentration. Peraclopone caused a dose-dependent decrease in cholesterol and a concomitant accumulation of provitamin D3 (7-dehydrocholesterol) in the skin, which is accompanied by an increase in the plasma level of 25-hydroxyvitamin D3. Treatment with peraclopone dramatically alters membrane sterol content in many membranes including the microvillus membrane of both the jejunum and ileum. In the jejunal microvillus membrane a major change in chemical composition occurred, presumably in response to the alteration in membrane sterol. The net result was a significant decline in both the static and dynamic component of membrane fluidity.

Smiles

ClC1=C(N2CCN(CC(CO/N=C/C3=CC=C(Cl)C=C3)O)CC2)C=CC=C1

Molecular Formula

C20H23Cl2N3O2

Molecular Weight

408.32

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
MBS5810784	Peraclopone

Peraclopone

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