3-Hydroxykynurenamine

• CAS Number :

  99362-47-7

• Target :

  Others|||Aryl Hydrocarbon Receptor

• Related Pathways :

  Others|||Immunology/Inflammation

• Bioactivity :

  3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-? mediated STAT1/NF-?? pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis by decreasing skin thickness, erythema, scaling and fissuring, reducing TNF, IL-1?, IFN-?, and IL-17 production, and inhibiting generation of effector CD8+ T cells. Similarly, in a mouse model of nephrotoxic nephritis, besides reducing inflammatory cytokines, 3-HKA improves proteinuria and serum urea nitrogen, overall ameliorating immune-mediated glomerulonephritis and renal dysfunction.This compound is unstable in powder form and other related salt forms are recommended.

• Smiles :

  C(CCN)(=O)C1=C(N)C(O)=CC=C1

• Molecular Formula :

  C9H12N2O2

• Molecular Weight :

  180.2

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C