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Tebufelone

CAT: 0931-T68155-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T68155-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
112018-00-5
Target
COX, LTR, Prostaglandin Receptor, Lipoxygenase
Related Pathways
Metabolism, Neuroscience, GPCR/G Protein, Immunology/Inflammation
Purity
0.9961
Bioactivity
Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has shown potent anti-inflammatory, analgesic and anti-reticulitis properties in various animal models. Tebufelone potently inhibits the formation of prostaglandins (PGE2) and blocks the formation of lipoxygenase pathway products [leukotriene (LTB4) ] in rat macrophages (IC50 = 20 microM) and human whole blood (IC50 = 22 microM) in vitro. = 20 microM) and human whole blood (IC50 = 22 microM) from the formation of lipoxygenase pathway products [leukotriene (LTB4) ] in vitro.
Smiles
OC1=C(C(C)(C)C)C=C(C(CCCC#C)=O)C=C1C(C)(C)C
Molecular Formula
C20H28O2
Molecular Weight
300.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5810719Tebufelone

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