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AZD0780

CAT: 0931-T64362-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T64362-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2455427-91-3
Target
Others
Related Pathways
Others
Purity
0.9974
Bioactivity
AZD0780 (EX-A6975, PCSK9-IN-12) is an orally active PCSK9 inhibitor with high affinity for PCSK9 (Kd < 200 nM) . It binds to a specific pocket in the C-terminal domain of PCSK9 without affecting the PCSK9–LDLR interaction. AZD0780 blocks the lysosomal trafficking of the PCSK9–LDLR complex and prevents PCSK9-induced LDLR degradation, making it useful for studies related to hypercholesterolemia.
Smiles
FC(F)Oc1cnc(N[C@H]2CC[C@@H](C2)Nc2ccc(cn2)-n2ccccc2=O)nc1
Molecular Formula
C20H20F2N6O2
Molecular Weight
414.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Laroprovstat

Laroprovstat is a small molecule drug. Laroprovstat has a monoisotopic molecular weight of 414.16 Da.

CAS Number2455427-91-3
PubChem CID154653847
IUPAC Name1-[6-[[(1S,3S)-3-[[5-(difluoromethoxy)pyrimidin-2-yl]amino]cyclopentyl]amino]-3-pyridinyl]pyridin-2-one
Molecular FormulaC20H20F2N6O2
Molecular Weight414.4
XLogP3.4
Topological Polar Surface Area92.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count30
Formal Charge0
Complexity641
SMILES
C1C[C@@H](C[C@H]1NC2=NC=C(C=C2)N3C=CC=CC3=O)NC4=NC=C(C=N4)OC(F)F
InChI
InChI=1S/C20H20F2N6O2/c21-19(22)30-16-11-24-20(25-12-16)27-14-5-4-13(9-14)26-17-7-6-15(10-23-17)28-8-2-1-3-18(28)29/h1-3,6-8,10-14,19H,4-5,9H2,(H,23,26)(H,24,25,27)/t13-,14-/m0/s1
InChIKey
NCHUWRLOTSAFFN-KBPBESRZSA-N
Chemical Structure
2D Structure
2D structure of Laroprovstat
CAS: 2455427-91-3
CID: 154653847
Formula: C20H20F2N6O2
MW: 414.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight414.4
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass414.16158023
Monoisotopic Mass414.16158023
Topological Polar Surface Area92.3 Ų
Heavy Atom Count30
Formal Charge0
Complexity641
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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CatalogName
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A24213-5AZD0780 (PCSK9-IN-12) 5mg

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