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Tetrahydrocoptisine

CAT: 0931-T4S2063-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T4S2063-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
4312-32-7
Target
PERK, Interleukin, p38 MAPK, NF-κB, ERK, Parasite, NO Synthase
Related Pathways
Microbiology/Virology, Immunology/Inflammation, Apoptosis, NF-κB, MAPK
Purity
0.9976
Bioactivity
1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may involve the inhibition of pulmonary inflammatory process. 3. Tetrahydrocoptisine has gastroprotective activity, is attributed to reducing NO production and adjusting the pro-inflammatory cytokine, inhibited neutrophil accumulation and NF-κB expression. 4. Tetrahydrocoptisine is an active anti-inflammatory constituent by inhibition of TNF-α, IL-6 and NO production possibly via down-regulation of NF-κB activation, phospho-ERK1/2 and phospho-p38MAPK signal pathways.
Smiles
C1Oc2cc3CCN4Cc5c6OCOc6ccc5CC4c3cc2O1
Molecular Formula
C19H17NO4
Molecular Weight
323.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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