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OncoFAP acetate

CAT: 0931-T41087L-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T41087L-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Immunology/Inflammation related
Related Pathways
Immunology/Inflammation
Purity
0.99873
Bioactivity
OncoFAP acetate is the highest-affinity small organic fibroblast activation protein (FAP) ligand reported to date, exhibiting a dissociation constant of 680 pM as measured by fluorescence polarization. OncoFAP derivatives, when administered intravenously in both fluorescent and radiolabeled forms, selectively accumulate in FAP-positive tumors while sparing normal tissues, enabling OncoFAP acetate to serve as modular components for targeted therapeutic delivery of radionuclides, CAR-T cells, or cytotoxic agents in oncology studies.
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OC(CNC(CNC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Molecular Formula
C108H174N36O22S.xC2H4O2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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