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NVP-BQS481

CAT: 0931-T212559-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212559-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1161925-41-2
Target
Others, Kinesin
Related Pathways
Cytoskeletal Signaling, Others
Bioactivity
NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs) .
Smiles
[C@@H](N(CC[C@@H](CF)N)C(CO)=O)(C(C)(C)C)C=1N(CC2=CC=CC=C2)C=C(N1)C3=C(F)C=CC(F)=C3
Molecular Formula
C27H33F3N4O2
Molecular Weight
502.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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