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JWJ-01-378

CAT: 0931-T212538-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212538-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
ERK, PROTACs, Trk receptor
Related Pathways
MAPK, Tyrosine Kinase/Adaptors, PROTAC
Bioactivity
JWJ-01-378 is a selective TRK PROTAC degrader. It effectively degrades wild-type TRK and TPM3-TRKA fusion proteins while inhibiting downstream pERK signaling, but shows limited degradation effects on TRK inhibitor-resistant mutants and ALK fusion proteins. Additionally, JWJ-01-378 effectively suppresses cancer cell proliferation.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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