JWJ-01-378
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
JWJ-01-378
Target :
ERK|||PROTACs|||Trk receptorRelated Pathways :
MAPK|||Tyrosine Kinase/Adaptors|||PROTACBioactivity :
JWJ-01-378 is a selective TRK PROTAC degrader. It effectively degrades wild-type TRK and TPM3-TRKA fusion proteins while inhibiting downstream pERK signaling, but shows limited degradation effects on TRK inhibitor-resistant mutants and ALK fusion proteins. Additionally, JWJ-01-378 effectively suppresses cancer cell proliferation.Shipping Conditions :
Cool packStorage Temperature :
-20°C
