HIF-1α-IN-8

CAT: 0931-T212496-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T212496-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

HIF/HIF Prolyl-Hydroxylase, IκB/IKK, Apoptosis, NF-κB, ROS

Related Pathways

NF-κB, Chromatin/Epigenetic, Metabolism, Apoptosis, Immunology/Inflammation

Bioactivity

HIF-1α-IN-8 is an orally active inhibitor of HIF-1α with an IC50 of 2.02 μM. It effectively suppresses the expression of inflammatory factors such as IL-6 and NO, reduces hypoxia-induced ROS production and apoptosis in C8-D1A cells, and inhibits the HIF-1α/IKKα/NF-κB signaling pathway. Additionally, it decreases the expression of proteins related to blood-brain barrier permeability. In a high-altitude cerebral edema (HACE) mouse model, HIF-1α-IN-8 lowers brain water content and oxidative stress levels. This compound is suitable for researching high-altitude cerebral edema (HACE) .

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-175521	HIF-1α-IN-8
sc-390933	HIF-3α (E-8)
sc-271835	HIF PHD2 (H-8)
BA7809-50	HIF-IN-1
PA1041-S	HIF-1α
sc-271835 HRP	HIF PHD2 (H-8) HRP
sc-271835 AC	HIF PHD2 (H-8) AC
sc-271835 FITC	HIF PHD2 (H-8) FITC
sc-271835 PE	HIF PHD2 (H-8) PE
sc-390933 X	HIF-3α (E-8) X

HIF-1α-IN-8

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