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RGN6024

CAT: 0931-T212175-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212175-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3055038-20-2
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Bioactivity
RGN6024 is an orally active, reversible small molecule that can penetrate the blood-brain barrier and acts as a microtubule (tubulin) destabilizer. It inhibits microtubule polymerization in both biochemical and cellular assays. RGN6024 binds to the colchicine-binding site of β-tubulin with affinity constants of Kd= 6.7 μM (SPR) and Kd= 7.4 μM (tryptophan assay), inducing G2/M phase arrest in glioblastoma (GB) cells. The compound remains effective in cells overexpressing βIII-tubulin. Additionally, RGN6024 is able to suppress tumor growth in glioblastoma (GB) xenograft mouse models. This compound is applicable for research in glioblastoma (GB) .
Smiles
O=C(NC1=NC=C(OC2=CN=C(N=C2)N3CCOCC3)S1)C45CC(OC)(C4)C5
Molecular Formula
C18H21N5O4S
Molecular Weight
403.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-176537-01RGN6024

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