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N-Didesmethyladitoprim

CAT: 0931-T212085-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212085-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
56066-19-4
Target
Antifolate, Drug Metabolite, Antibacterial
Related Pathways
Cell Cycle/Checkpoint, Microbiology/Virology, Metabolism
Bioactivity
N-Didesmethyladitoprim is a metabolite of Aditoprim, which acts as a selective inhibitor of bacterial dihydrofolate reductase (DHFR) . Aditoprim exhibits inhibitory concentration (IC50) values of 47 nM for Escherichia coli and 520 nM for Lactobacillus casei DHFR. It impedes the reduction of dihydrofolate to tetrahydrofolate. Aditoprim demonstrates broad-spectrum antibacterial activity and excellent pharmacokinetics.
Smiles
N=1C=C(C(=NC1N)N)CC2=CC(OC)=C(N)C(OC)=C2
Molecular Formula
C13H17N5O2
Molecular Weight
275.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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