Products for Research Use Only
RegisterLogin

SLC-391

CAT: 0931-T212014-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T212014-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1783825-18-2
Target
SARS-CoV, TAM Receptor
Related Pathways
Tyrosine Kinase/Adaptors, Microbiology/Virology
Bioactivity
SLC-391 is a selective, orally active AXL inhibitor with an IC50 of 9.6 nM [SLC-391 exhibits antiviral activity].
Smiles
N=1N=C(OC1C=2C=C(C=NC2N)C=3C=NN(C3)C4CCNCC4)CC5CC5
Molecular Formula
C19H23N7O
Molecular Weight
365.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Dsp7A26K25

AXL Inhibitor SLC-391 is an orally bioavailable and selective inhibitor of the receptor tyrosine kinase AXL (UFO), with potential immunostimulating and antineoplastic activities. Upon oral administration, SLC-391 targets, binds to and prevents the activation of AXL. This blocks AXL-mediated signal transduction pathways, and inhibits both AXL-mediated tumor cell growth, proliferation and migration and AXL-mediated immunosuppression. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases, is overexpressed by many tumor cell types and also expressed in a variety of immune cells including macrophages, natural killer (NK) cells, and regulatory T-cells (Tregs). It plays a key role in tumor cell proliferation, survival, invasion and metastasis, and is a mediator of immunosuppression. Its expression is associated with drug resistance and poor prognosis.

CAS Number1783825-18-2
PubChem CID118110201
IUPAC Name3-[5-(cyclopropylmethyl)-1,3,4-oxadiazol-2-yl]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
Molecular FormulaC19H23N7O
Molecular Weight365.4
XLogP1.4
Topological Polar Surface Area108
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity498
SMILES
C1CC1CC2=NN=C(O2)C3=C(N=CC(=C3)C4=CN(N=C4)C5CCNCC5)N
InChI
InChI=1S/C19H23N7O/c20-18-16(19-25-24-17(27-19)7-12-1-2-12)8-13(9-22-18)14-10-23-26(11-14)15-3-5-21-6-4-15/h8-12,15,21H,1-7H2,(H2,20,22)
InChIKey
JYVSYFGHYFXYBE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dsp7A26K25
CAS: 1783825-18-2
CID: 118110201
Formula: C19H23N7O
MW: 365.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight365.4
XLogP31.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass365.19640838
Monoisotopic Mass365.19640838
Topological Polar Surface Area108 Ų
Heavy Atom Count27
Formal Charge0
Complexity498
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T18551(+) -Biotin-SLC
TYD-02808-01Biotin-SLC-NHS Ester
TP2780-01Influenza A NP (383-391) (HLA-B27)
TP1527-01CEF8, Influenza Virus NP (383-391)
T68734-01Opc 3911
TPL0096-01Compound 3913-17-5

Alternative Products

CatalogName
HY-177332SLC-391
B2282-50KX2-391
EMk27616Monkey SLC (SLC) ELISA Kit
GTR19274525-01P4Q-391
289547-01SLC- (+) -Biotin
HY-130887-01(+) -Biotin-SLC
MBS5771410(+)-Biotin-SLC
OACD07339-1MLSLC Antibody
GTR19163474-01SLC-0111

Popular Products