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LC-MF-4

CAT: 0931-T211928-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211928-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs, ATPase, FGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Membrane transporter/Ion channel, PROTAC
Bioactivity
LC-MF-4 is a selective FGFR3 PROTAC degrader with a DC50 of 30.89 nM in KMS-11 cells. It inhibits the metabolic functions of FGFR3-TACC3 fusion-positive cancers by reducing ATP synthesis and suppressing mitochondrial biogenesis genes. LC-MF-4 demonstrates potent anti-tumor activity in the Ba/F3-FGFR3-TACC3 xenograft mouse model and is applicable for research on FGFR3 gene mutation cancers such as bladder cancer and urothelial carcinoma (UC) .
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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