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5α-Tetrahydrocorticosterone

CAT: 0931-T211720-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211720-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
600-63-5
Target
Glucocorticoid Receptor, Endogenous Metabolite, Drug Metabolite
Related Pathways
Metabolism, Endocrinology/Hormones
Bioactivity
5α-Tetrahydrocorticosterone (5α-HB) is an endogenous steroid that acts as an agonist of the glucocorticoid receptor (GR) and a metabolite of corticosterone. It serves as an effective topical anti-inflammatory agent in vivo. In rat liver cells, it decreases the binding of metabolites to the glucocorticoid receptor-corticosterone and its 5α-reduced metabolites, with a Kd value of 268 nM. 5α-Tetrahydrocorticosterone is applicable in research on inflammatory skin diseases.
Smiles
C[C@@]12[C@@]3([C@]([C@]4([C@](C)(C[C@@H]3O)[C@@H](C(CO)=O)CC4)[H])(CC[C@]1(C[C@H](O)CC2)[H])[H])[H]
Molecular Formula
C21H34O4
Molecular Weight
350.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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