CIDD-8633

CAT: 0931-MF-0118545-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118545-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1428356-95-9
Target
Interleukin|||Apoptosis|||Caspase|||Discoidin Domain Receptor (DDR)
Related Pathways
Tyrosine Kinase/Adaptors|||Apoptosis|||Proteases/Proteasome|||Immunology/Inflammation
Bioactivity
CIDD-8633 is a potent inhibitor of DDR2 with an IC50 of 6.105 ?M. It significantly suppresses the proliferation of MIA-PaCa-2 and AsPC-1 cells, with IC25 values of 4.0 and 5.5 ?M, respectively. Additionally, CIDD-8633 hinders cell migration, arrests the cell cycle, induces apoptosis (apoptosis), and substantially reduces the growth of pancreatic ductal adenocarcinoma (PDAC) tumors. This compound is applicable in pancreatic cancer research, including studies on PDAC.
Smiles
O=C(NC1=CC=C(C=C1)NC2=NC(=NC(=C2)C)NCC)COC3=NN=C(C=C3)N4N=CC=C4
Molecular Formula
C22H23N9O2
Molecular Weight
445.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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