ATM-IN-2

CAT: 0931-MF-0063469-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0063469-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis|||ATM/ATR
Related Pathways
PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair|||Apoptosis
Bioactivity
ATM-IN-2 is a selective, orally active ATM inhibitor with an IC50 of 4 nM. It demonstrates high kinase selectivity, being over 700 times more selective relative to PIKK family members. ATM-IN-2 exerts its anti-tumor effects and promotes apoptosis by inhibiting ATM phosphorylation and downstream signaling pathways (p53, H2AX) . It is applicable for research in solid tumors, such as colon cancer.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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