Neuroprotective agent 12

• Target :

  ROS|||PDE|||NF-?B

• Related Pathways :

  NF-?B|||Immunology/Inflammation|||Metabolism

• Bioactivity :

  Neuroprotective agent 12 is an orally active compound capable of crossing the blood-brain barrier, offering significant neuroprotective properties. It exhibits robust antioxidant and anti-inflammatory effects, markedly inhibiting cell death induced by glutamate and acrolein. This agent reduces the expression of PDE4B while elevating levels of HO-1, p-CREB, and BDNF. In a traumatic brain injury (TBI) mouse model, Neuroprotective agent 12 demonstrates potent neuroprotection and holds potential for research into TBI and other central nervous system disorders.

• Smiles :

  O(C1=C(OC)C=C(/C=C/C(NC2=CC=C(N(C)C)C=C2)=O)C=C1)C3CCCC3

• Molecular Formula :

  C23H28N2O3

• Molecular Weight :

  380.48

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2522599-69-3