Neuroprotective agent 12

• Target:

  ROS|||PDE|||NF-?B

• Related Pathways:

  NF-?B|||Immunology/Inflammation|||Metabolism

• Bioactivity:

  Neuroprotective agent 12 is an orally active compound capable of crossing the blood-brain barrier, offering significant neuroprotective properties. It exhibits robust antioxidant and anti-inflammatory effects, markedly inhibiting cell death induced by glutamate and acrolein. This agent reduces the expression of PDE4B while elevating levels of HO-1, p-CREB, and BDNF. In a traumatic brain injury (TBI) mouse model, Neuroprotective agent 12 demonstrates potent neuroprotection and holds potential for research into TBI and other central nervous system disorders.

• Smiles:

  O(C1=C(OC)C=C(/C=C/C(NC2=CC=C(N(C)C)C=C2)=O)C=C1)C3CCCC3

• Molecular Formula:

  C23H28N2O3

• Molecular Weight:

  380.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2522599-69-3