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Deglycobleomycin

CAT: 0931-T210875-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210875-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
78314-57-5
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
Deglycobleomycin is an RNA cleaving agent that targets r (CUG) repeat sequences. By binding with small molecules that recognize r (CUG) exp, Deglycobleomycin can selectively cleave r (CUG) exp. Its efficiency in cleaving DNA is considerably lower than that of Bleomycin A5 (Pingyangmycin), but it exhibits enhanced selectivity for r (CUG) exp. Deglycobleomycin is useful for research on diseases associated with r (CUG) repeat expansions, such as myotonic dystrophy type 1, and the development of drugs aimed at precise targeting and cleavage of pathogenic RNA.
Smiles
[C@H](NC[C@@H](C(N)=O)N)(CC(N)=O)C=1N=C(C(N[C@@H]([C@@H](O)C2=CN=CN2)C(N[C@@H]([C@H]([C@@H](C(N[C@H](C(NCCC3=NC(=CS3)C4=NC(C(NCCCCNC(=N)N)=O)=CS4)=O)[C@@H](C)O)=O)C)O)C)=O)=O)C(C)=C(N)N1
Molecular Formula
C42H63N19O10S2
Molecular Weight
1058.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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CatalogName
GTR19263383-01Deglycobleomycin

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