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Modzatinib

CAT: 0931-T210785-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210785-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2411407-25-3
Target
JAK, Tyrosine Kinases
Related Pathways
Chromatin/Epigenetic, Angiogenesis, JAK/STAT signaling, Stem Cells, Tyrosine Kinase/Adaptors
Bioactivity
Modzatinib (ITKkinase-IN-1) (compound I) is an inhibitor targeting ITK kinase with an IC50 of 8 nM in Jurkat cells, useful for researching inflammatory diseases. In hPBMC cells, it inhibits JAK3 with an IC50 of 23 nM (based on IL-2/pSTAT5 levels) and shows no inhibitory effect on JAK2.
Smiles
N(C1=C2C(=CNC2=NC=N1)[C@@H]3C(F)(F)C3)[C@H]4CN(C(C=C)=O)[C@@H](C)CC4
Molecular Formula
C18H21F2N5O
Molecular Weight
361.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19263296-01Modzatinib

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