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HTS05585

CAT: 0931-T210778-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210778-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
696643-14-8
Target
MIF
Related Pathways
Immunology/Inflammation
Bioactivity
HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.
Smiles
N=1OC(=CC1C=2C=CC=CC2)C=3N=C4C=C(C=CN4C3)CC
Molecular Formula
C18H15N3O
Molecular Weight
289.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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